Design, preparation, and selection of DNA-encoded dynamic libraries† †Electronic supplementary information (ESI) available: Materials and general methods, experimental details, library selection and sequencing methods and fold enrichment calculations. See DOI: 10.1039/c5sc02467f Click here for additional data file.

A platform for high-throughput screening of DNA-encoded catalyst libraries in organic solvents† †Electronic supplementary information (ESI) available: Supplemental figures, supporting data, detailed experimental methods, and molecular characterisations. See DOI: 10.1039/c7sc02779f Click here for additional data file.

We have developed a novel high-throughput screening platform for the discovery of small-molecules catalysts for bond-forming reactions. The method employs an in vitro selection for bond-formation using amphiphilic DNA-encoded small molecules charged with reaction substrate, which enables selections to be conducted in a variety of organic or aqueous solvents. Using the amine-catalysed aldol reac...

Nucleophilic addition and substitution at coordinatively saturated boron by facile 1,2-hydrogen shuttling onto a carbene donor† †Electronic supplementary information (ESI) available: General experimental details, characterization data for all reported compounds and details of the DFT calculations. CCDC 1563216–1563221. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03193a Click here for additional data file. Click here for additional data file.

Borylation of fluorinated arenes using the boron-centred nucleophile B(CN)3 2– – a unique entry to aryltricyanoborates† †Electronic supplementary information (ESI) available: Additional tables, experimental information, analytical data and details of the DFT calculations. CCDC 1548893–1548910. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02249b Click here for additional data file. Click here for additional data file.

Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties† †Electronic supplementary information (ESI) available: Synthetic experimental details, DFT calculation details, additional figures (relevant NMR data) and schemes (synthetic schemes for peptide and amino acid preparation). CCDC 1400134. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc03187g Click here for additional data file. Click here for additional data file.

α-CH acidity of alkyl–B(C6F5)2 compounds – the role of stabilized borata-alkene formation in frustrated Lewis pair chemistry† †Electronic supplementary information (ESI) available: Details of the DFT calculations and experimental details. CCDC 1006899–1006903. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc01711k Click here for additional data file. Click here for additional data file.